For high resolution electron microscope studies, BioSite gold conjugates offer the best quality in size distribution, freedom from clustering and sensitivity. In addition, because of the exceptionally high concentration of the conjugates as supplied, very small amounts of material (e.g. 1?) are required for each incubation, making the technique a very inexpensive and efficient one. Immunogold conjugates are made from the highest quality components. All BioSite conjugated immunoglobulins are affinity purified and monospecific, giving very low cross reactivity.